By a sensible cyclic application of anabolic/androgenic steroids we mean several timed intake schedules which, on the one hand, observe the basic rules for the intake of steroids and, on the other hand, are coordinated with the goal of the individual athlete and particularly the characteristics of the relative steroids that are taken. Principally, one should begin with a relatively low dosage and gradually and evenly increase it in order to maintain the positive nitrogen balance in the muscle cell. Since oral steroids begin to show their effect within several days and result in quite a rapid saturation of the receptors, their intake is limited to 6-8 weeks. Following that, the use of steroids is discontinued or the athlete switches to another (oral) steroid. It is also shown that the combination of two to three steroids in moderate dosages is much more effective and also guarantees a longer duration of effect than when only one steroid is taken in a high dosage. With the right combinations one will be able to obtain a synergetic effect if the athlete pays attention to selecting steroids which have different influences on the factors of strength, tissue buildup, and recovery. A stack which fulfills these requirements, for example, would be Deca-Durabolin as an anabolic basic steroid with depot character, Sustanon to promote recovery and general mass buildup, and Oxandrolone to increase body strength. The stimulation of various receptor types over a limited period leads to the best results. The buildup- effect can be maintained over several months if the steroid combination is completely changed no later than every eight weeks, if the athletes alternate the stronger and mostly androgenic cycles with the weaker and predominantly anabolic cycles and when the dosages are continuously graduated. A long and even reduction of the doses at the end of the cycle helps in normalizing the body functions and preparing the organism for a suspension of the intake.
Valproic acid was first synthesized in 1882 by Beverly S. Burton as an analogue of valeric acid , found naturally in valerian .  Valproic acid is a carboxylic acid , a clear liquid at room temperature. For many decades, its only use was in laboratories as a "metabolically inert" solvent for organic compounds. In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure activity. He found it prevented pentylenetetrazol -induced convulsions in laboratory rats .  It was approved as an antiepileptic drug in 1967 in France and has become the most widely prescribed antiepileptic drug worldwide.  Valproic acid has also been used for migraine prophylaxis and bipolar disorder.