Pharmacokinetic studies in men with Topicort® (desoximetasone) Ointment % with tagged desoximetasone showed no detectable level (limit of sensitivity: μg/mL) in 1 subject and and μg/mL in the remaining 2 subjects in the blood when it was applied topically on the back followed by occlusion for 24 hours. The extent of absorption for the ointment was 7% based on radioactivity recovered from urine and feces . Seven days after application, no further radioactivity was detected in urine or feces. Studies with other similarly structured steroids have shown that predominant metabolite reaction occurs through conjugation to form the glucuronide and sulfate ester.
Few things are more maddening than an itch. And summer is prime time for all kinds of creepy-crawly sensations, often accompanied by mysterious lumps, bumps, cracking, crusting, swelling, and oozing (delightful!).
"Most itching has an obvious cause, such as bug bites or dry skin," says Ronald Brancaccio, MD, director of the Skin Institute of New York and clinical professor of dermatology at New York University School of Medicine. "But sometimes an itch or the rash that goes with it can be hard to figure out, even if it has a straightforward cause like an allergic reaction."