Potency of ocular steroids

The most promising drug candidate among cortienic acid-based derivatives synthesized by Bodor and colleagues was loteprednol etabonate (LE; chloromethyl 17 α -ethoxycarbonyloxy-11 β -hydroxy-3-oxoandrosta-1,4-diene, 17 β -carboxylate) [ 20 ]. LE is the 17 β -chloromethyl ester of Δ1-cortienic acid with a 17 α -etabonate moiety and was predicted to undergo rapid deesterification to an inactive carboxylic acid metabolite after exerting its effect, thereby minimizing the likelihood of toxicity.

Potency of ocular steroids

potency of ocular steroids

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