Cyclooxygenase (COX) receptor is a dual-function receptor that bound to the membrane which acts to catalyze two important stages in the formation of prostanoide, namely cyclooxigenation and peroxidation. Cyclooxigenation stage is the stage in which COX cyclization process and the addition of two molecules of oxygen to arachidonic acid to form prostaglandin G2 (PGG2). While the stage is the stage of the reduction of the peroxidation of PGG2 endoperoxide become unstable compound called prostaglandine H2 (PGH2). The purpose of this study is to determine the features that are important pharmacophore on anti-inflammatory activity of compounds on COX-2 receptor. Modeling and determination pharmacophore features created using the program MOE application version 2009 Virtual screening of chemical compounds to look for natural ingredients in accordance with pharmacophore features that have been made. Molecular docking to study ligand-receptor interactions, performed using MOE.
East-Indian Lemon Grass (Cymbopogon flexuosus), also called Cochin Grass or Malabar Grass (Malayalam: ?????????????(inchippullu), is native to Cambodia, India, Sri Lanka, Burma,and Thailand while the West-Indian lemon grass (Cymbopogon citratus), also known as serai in Malay, is assumed to have its origins in Malaysia. Indonesian people used to called it serai too or sereh. While both can be used interchangeably, C. citratus is more suited for cooking. In India C. citratus is used both as a medical herb and in perfumes. Cymbopogon citratus is consumed as a tea for anxiety in Brazilian folk medicine, but a study in humans found no effect. The tea caused a recurrence of contact dermatitis in one case.