Topical ocular administration of % dexamethasone ( mg/kg/day) on gestational days 10 to 13 produced embryofetal lethality and a high incidence of cleft palate in mice. A dose of mg/kg/day in the mouse is approximately 3 times an Ozurdex ® injection in humans ( mg dexamethasone) on a mg/m2 basis. In rabbits, topical ocular administration of % dexamethasone throughout organogenesis ( mg/kg/day, on gestational day 6 followed by mg/kg/day on gestational days 7-18) produced intestinal anomalies, intestinal aplasia, gastroschisis and hypoplastic kidneys. A dose of mg/kg/day in the rabbit is approximately 4 times an Ozurdex ® injection in humans ( mg dexamethasone) on a mg/m2 basis.
Prostaglandin analogs may cause changes in iris color and eyelid skin, growth of eyelashes , stinging, blurred vision , eye redness, itching, and burning. Beta blockers' side effects include low blood pressure , reduced pulse rate , fatigue , shortness of breath, and in rare occasions, reduced libido and depression . Alpha agonists can cause burning or stinging, fatigue, headache , drowsiness , dry mouth and nose , and also they have a higher likelihood of allergic reaction. Carbonic anhydrase inhibitors may cause stinging, burning, and eye discomfort.