Biosintesis kolesterol dan steroid

HMG-CoA reductase is subject to enzyme-mediated autoregulation and feedback inhibition. It is activated by the enzyme hydroxymethylglutaryl-CoA reductase (NADPH) kinase and deactivated by hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase [ 3 ], while feedback inhibition occurs by means of two mechanisms: sterol regulatory element binding proteins (SREBPs) and oxysterols [ 39 ]. The latter have been demonstrated to promote ubiquitination and degradation of HMG-CoA reductase [ 13 ]. There is interest in promoting enzyme degradation as an alternative strategy for pathway inhibition [ 4 , 9 ].

Biosintesis kolesterol dan steroid

biosintesis kolesterol dan steroid

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biosintesis kolesterol dan steroidbiosintesis kolesterol dan steroidbiosintesis kolesterol dan steroidbiosintesis kolesterol dan steroidbiosintesis kolesterol dan steroid

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